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Lit Matters #1: PECARN for TBI in Those < 3 Months Old

Mizuho Morrison, DO and Matthew DeLaney, MD, FACEP, FAAEM

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The summary below is from an episode of ERcast: Clinical Perspectives

PECARN performs differently in infants younger than 3 months with minor blunt head trauma: it is very good at identifying very low risk for clinically important TBI, but not for every CT-visible injury. In this age group, the key decision is whether you are trying to avoid missing intervention-requiring trauma or all radiographic TBI.

PECARN in Infants Under 3 Months

  • Clinically important TBI risk: Among infants under 3 months who met PECARN low-risk criteria, clinically important TBI was rare at 0.2%, supporting the rule as a safety tool for the injuries that change immediate management.
  • CT injury miss rate: Low-risk infants still had TBI on CT in 5.1%, a reminder that PECARN is stronger for ruling out clinically important TBI than for excluding every radiographic injury.
  • Skull fracture signal: Even in the PECARN low-risk group, skull fracture appeared on CT in 4.6%, reinforcing that low risk does not mean no injury in very young infants.
  • Negative subgroup finding: Infants who were PECARN low risk and had no additional concerning findings outside the rule had no clinically important TBIs. We get into why that distinction matters in the episode.
  • Clinical goal mismatch: The practical question is whether your target is neurosurgical or airway-threatening injury versus all CT-detected TBI, because the rule performs much better for the first goal than the second.

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