COVID Antibodies and Immunity
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Dr. Mizuho Morrison & Dr.Jenny Beck Esmay both having had covid themselves, briefly discuss the clinical course and what presence of IgM vs. IgG signifies. They discuss what we currently know about antibody testing (national availability, reliability, sensitivity) as well as convalescent plasma transfusion (CPT) and criteria for donation vs. recipient.
published on 6/1/20
References:
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Rajendran K et al. Convalescent plasma transfusion for the treatment of COVID-19: Systematic review. J Med Virol. 2020 May https://www.ncbi.nlm.nih.gov/pubmed/32356910
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Shen C et al. Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma. JAMA. 2020 Mar 27. doi: 10.1001/jama.2020.4783
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Luke T et al. Meta-analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment? Ann Intern Med. 2006 Oct 17; 145(8): 599–609.
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Casadevall A, Scharff MD. Serum therapy revisited: animal models of infection and development of passive antibody therapy. Antimicrobial Agents and Chemotherapy Aug 1994, 38 (8) 1695-1702.
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Jenkins J et al. The Effectiveness of Convalescent Plasma and Hyperimmune Immunoglobulin for the Treatment of Severe Acute Respiratory Infections of Viral Etiology: A Systematic Review and Exploratory Meta-analysis. J Infect Dis. 2015 Jan 1; 211(1): 80–90.
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Hung I et al. Hyperimmune IV immunoglobulin treatment: a multicenter double-blind randomized controlled trial for patients with severe 2009 influenza A(H1N1) infection. Chest. 2013 Aug; 144(2): 464–473.
Additional references:
Marshall R., Mr. - July 15, 2020 9:07 PM
Dr. Morrison,
It has been six weeks since this article was published. Any updates on the immunity study? Have you heard of any cases of reinfection after recovery in confirmed COVID 19 positive patients?
Mizuho M., DO - July 19, 2020 3:39 PM
Hi Marshall, Thanks for your questions. No robust data updates quite yet . We will continue to monitor and report when something substantial is published. In terms of re-infection, there have only been few case reports on this, and lots of questions re: accuracy of diagnosis (ie: was it a single infection that improved and then resurged? ; vs questionable initial infection with similar sxs that was proven on "2nd" infection). More to come! Thanks for listening Marshall!