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Bonus Short - COVID 19: Hot Topics and Lit Review

Stephen Biederman MD and Thomas Robertson MD
00:00
23:04

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There are so many active threads, subthreads, and sub-sub-threads of conversation in the medical community surrounding the COVID-19 pandemic. In this Hippo Education Short, Drs. Tom Robertson and Steve Biederman of Primary Care RAP’s Paper Chase take 4 hot topics in COVID-19 and examine the literature behind them. They look into the epidemiology of the outbreak in the U.S. and lessons learned, the sensitivity and specificity of SARS-CoV-2 testing, the rates of co-infection with other respiratory viruses, and convalescent plasma as a potential therapy.

References:

  1. McMichael TM, Currie DW, Clark C, et al for the CDC COVID-19 Investigation Team. Epidemiology of COVID-19 in a long-term care facility in King County, Washington. N Engl J Med. Published online March 27, 2020. doi:10.1056/NEJMoa2005412

  2. Wang W, Xu Y, Gao R, et al. Detection of SARS-CoV-2 in different types of clinical specimens. JAMA. Published online March 11, 2020. doi:10.1001/jama.2020.3786

  3. Lauer SA, Grantz KH, Bi Q, et al. The incubation period of coronavirus disease 2019 (COVID-19) from publicly reported confirmed cases: estimation and application. Ann Intern Med. Published online March 10, 2020. doi: 10.7326/M20-0504

  4. Shah N. Higher co-infection rates in COVID-19. Data from Stanford University published in Medium at the request of the California Department of Public Health. Published March 18, 2020. https://medium.com/@nigam/higher-co-infection-rates-in-covid19-b24965088333

  5. Ding Q, Lu P, Fan Y. The clinical characteristics of pneumonia patients coinfected with 2019 novel coronavirus and influenza virus in Wuhan, China. J Med Virol. 2020; 1– 7. https://doi.org/10.1002/jmv.25781

  6. Yang Y, Yang M, Shen C, et al. Evaluating the accuracy of different respiratory specimens in the laboratory diagnosis and monitoring the viral shedding of 2019-nCoV infections. medRxiv. 2020 Feb 17;2020.02.11.20021493.

  7. Wolfel R, Corman VM, Guggemos W, et al. Clinical presentation and virological assessment of hospitalized cases of coronavirus disease 2019 in a travel-associated transmission cluster [Internet]. Infectious Diseases (except HIV/AIDS); 2020 Mar. Available from: http://medrxiv.org/lookup/doi/10.1101/2020.03.05.20030502

  8. Ai T, Yang Z, Hou H, et al. Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases. Radiology. Published online February 26, 2020. https://doi.org/10.1148/radiol.2020200642 

  9. Shen C, Wang Z, Zhao F, et al. Treatment of 5 critically ill patients with COVID-19 with convalescent plasma. JAMA. Published online March 27, 2020. doi:10.1001/jama.2020.4783

Lori J the PA -

Great update, thanks!!!

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