Start with a free account for 3 free CME credits. Already a subscriber? Sign in.

The MOCA-Peds eBook is Here!

The Peds RAP team has created an easily searchable eBook with detailed answers to all of the 45 MOCA-Peds learning objectives to help you confidently pass your 2021 MOCA-Peds.

This free eBook is available to anyone who creates a Peds RAP account, so sign up for a free account today, and tell your friends!

A Site for Psoriasis

Paper Chase #5 - In Utero Acetaminophen and Development Disorder Risk

Roy Benaroch, MD and Geoffrey R. Simon, MD
00:00
09:26
Sign in or subscribe to listen

No me gusta!

The flash player was unable to start. If you have a flash blocker then try unblocking the flash content - it should be visible below.

Tag Evidence based medicine EBM

The authors argue cord biomarkers of acetaminophen exposure was associated with an increased risk of both ADHD and autism spectrum disorders. There are however methodological concerns and the Benaroch would not draw any conclusions from this study. 

To view chapter written summaries, you need to subscribe.

Sign up today for full access to all episodes.

Arsany B. -

Hello all,

This has been a very interesting segments and I appreciate your comments and thoughts. I also just came across a study from 2017 published in Pediatrics and then used AAP Grand Rounds February 2018 with more details. I would love to hear your feedback given the summation of the 2 studies.

Study: https://pediatrics.aappublications.org/content/140/5/e20163840?ijkey=5a468a97567e7c5981d860f9b26a1b66e148db88&keytype2=tf_ipsecsha

AAP Grand Rounds: https://aapgrandrounds.aappublications.org/content/39/2/17

Thank you.
Arsany Basily from Seattle, WA.

Solomon B., MD -

Hi Arsany- thx for writing in! Here is what our paper chaser Roy had to say about this: Roy says:
this is an observational study, so it can pick up potential associations, but cannot be used to infer causality. They've tried to adjust for confounders, but as always with these studies if you miss one more more confounders, you can reach the wrong conclusions. The authors of this study claim in their conclusion that though the short-term use of acetaminophen was negatively associated with later ADHD (meaning it was associated with a DECREASED risk), long term use was associated with an increased risk. There are some odd things, though. The risk from acetaminophen used for 3 or 4 weeks was substantially more than the risk from longer term use, which is biologically implausible. Also, the risk found based on paternal use was actually in the same ballpark as maternal use, which also makes no sense if the medication itself were modulating the effect via placental transfer.

So, bottom line, I'm not sure what to make of this. I would say at this point there isn't convincing evidence of harm from APAP during pregnancy and the risk of ADHD.

Hope this helps (and thank you to Roy!)

Arsany B. -

Thank you so much. I appreciate the feedback.

To join the conversation, you need to subscribe.

Sign up today for full access to all episodes and to join the conversation.

To download files, you need to subscribe.

Sign up today for full access to all episodes.
Peds RAP April 2020 Written Summary 211 KB - PDF

To earn CME for this chapter, you need to subscribe.

Sign up today for full access to all episodes and earn CME.

0.25 Free AMA PRA Category 1 Credits™ certified by Hippo Education or 0.25 Free AAP credits certified by AAP (2020)

  1. Complete Quiz
  2. Complete Evaluation
  3. Print Certificate

3.25 AMA PRA Category 1 Credits™ certified by Hippo Education or 3.25 AAP credits certified by AAP (2020)

  1. Complete Quiz
  2. Complete Evaluation
  3. Print Certificate