Paper Chase #3 | Breast Cancer MortalityFrom May 2018, The Buzz That Won't Quit
This simulation modeling study reports that breast cancer mortality reductions in US women were from both advances in screening and adjuvant therapy.4min 57Andrew Buelt, DO and Joe Weatherly, DO
Contralateral Breast MastectomiesFrom April 2018, Will You Be My Facebook Friend?
After their deep dive into the evidence, Jake and Andrew conclude that contralateral prophylactic mastectomies should not play a role in the management of breast cancer for most patients. The risk of recurrence in the contralateral breast is simply too small to justify exposing patients to the …18min 21Andrew Buelt, MD and Jake Anderson, MD
DOACs for VTE in Cancer - Tom DeLoughery for the Win!From March 2018, DOACs for VTE in Cancer - Tom DeLoughery for the Win!
Tom DeLoughery predicted a new practice pattern in an earlier PC RAP and he turned out to be totally right, so we’re proud to say “you heard it here first.”5min 28Andrew Buelt, DO
Paper Chase #1 - Hormonal Contraception & Breast CancerFrom March 2018, What’s Your (Code) Status?
The risk of breast cancer was higher in women who were currently or had recently used contemporary hormonal contraceptives when compared to women that never utilized hormonal contraception.4min 42Andrew Buelt, DO and Joe Weatherly, DO
Cancer & ThrombosisFrom February 2018, The Tragically Sore Hip
Tom Deloughery shares his wisdom on all things cancer and thrombosis. First, he reviews why patients with cancer are more likely to have clots, then reviews some aspects of thrombosis that are unique to this population. Lastly, he discusses treatment standards, nuances and controversies.18min 54Tom Deloughery, MD and Matthieu DeClerck, MD
Fever of Unknown Origin (FUO)From January 2018, A Feverish Frenzy!
In this intro, Neda and Heidi review a case of Fever of Unknown Origin, with attention to differential diagnosis generation and appropriate work up. A female patient in her late 20s presents with recurrent fevers and weight loss. After working through a differential which includes malignancy …12min 55Neda Frayha, MD and Heidi James, MD
Paper Chase #5 - Plasma EBV as Screening Tool for Head & Neck CancerFrom November 2017, Lytes and Bites
Screening for EBV DNA is plasma allows for earlier detection of nasopharyngeal cancers, often detecting them before they would have been clinically apparent. Catching these cancers earlier will optimistically lead to higher survival and decreased morbidity rates. •5min 19Andrew Buelt, DO and Joe Weatherly, DO
A Ghoulish UpdateFrom October 2017, It's Bloody Halloween!
Andrew and Heidi talk about the potential role of ASA in preventing colorectal cancer, compare fracture risks associated with common anticoagulants, and go on a bit of a tirade about lung cancer screening. •12min 13Heidi James, MD and Andrew Buelt, DO
Paper Chase 1 - HPV VaccineFrom June 2017, Legions of Lesions
A two-dose regime of non-valent HPV vaccine is at least as effective as the traditionally recommended 3 dose regime.4min 56Andrew Buelt, DO and Joe Weatherly, DO
Prostate 2.0From June 2017, Legions of Lesions
Casey Parker synthesizes the recommendations from prostate cancer screening guidelines around the world and provides us with a patient centred approach. He recommends providing patients with paper handouts or web sites with clear and realistic data about screening. At a follow-up visit, the harms …18min 19Casey Parker, MD
HPV VaccinationFrom June 2017, Legions of Lesions
Andrew and Jake give us an update on all that’s new in the land of HPV vaccination. Makers of the mono and quadri-valent will be shortly withdrawing them from the market, leaving the nine-valent vaccine as the only option. Increased valency means broader coverage for wart and cervical causing …9min 56Andrew Buelt, DO and Jake Anderson, MD
Cancer Guidelines, Anti-Diarrheal Meds and Codeine in KidsFrom May 2017, Cancer Guidelines, Anti-Diarrheal Meds and Codeine in Kids
Andrew and Vanessa bring us what’s hot in medical news this month: the USPSTF revamps its prostate cancer guidelines, people are overdosing on anti-diarrheal medications (no, we’re not full of it), and the FDA warns against codeine and tramadol use in children.6min 31Andrew Buelt, DO and Vanessa Cardy, MD
Paper Chase 3: Breast Cancer Screening in DenmarkFrom April 2017, Antibiotics in the Lyme-Light
Data from the Danish mammographic screening program suggests that advanced cancers (tumours over 20mm in size) are just as common in screened as in unscreened women. It also found that roughly a third of all tumors found by screening represented “overdiagnosis”, meaning radiographically present …6min 7Andrew Buelt, DO and Joe Weatherly, DO
The Primary Care RAP Hot Sheet: March 2017From March 2017, The Primary Care RAP Hot Sheet: March 2017
This month, Andrew and Joe suffer from some entertaining loosening of associations as they connect obscure March holidays to recent studies on flexible sigmoidoscopy, lung cancer screening, and metformin in chronic kidney disease. (Spoiler: Awkward Moment Day is an actual thing.) •5min 36Andrew Buelt, DO, Joe Weatherly, DO, and Heidi James, MD
The Primary Care RAP Hot Sheet: February 2017From February 2017, The Primary Care RAP Hot Sheet: February 2017
Dr. Heidi James and Dr. Brandon Grove bring you a teen with cancer who starts a kindness revolution and the Brits kill what little joy there is in toast.7min 47Heidi James, MD and Brandon Grove, MD
Paper Chase 5: Whole Brain Radiotherapy (WBRT)From February 2017, Sweat Puddled, Brains Muddled
Whole brain radiotherapy (WBRT) and dexamethasone are widely used to treat brain metastases from non-small cell lung cancer. This study aimed to establish whether WBRT could be omitted without a significant effect on survival or quality of life. Authors concluded that WBRT provides little …5min 17Andrew Buelt, DO and Joe Weatherly, DO
Paper Chase 1 - Consider the Prostate, AgainFrom January 2017, Bones Lose Their Autonomy
Median prostate-related cancer death at 10 years was low, irrespective of treatment assignment, with no significant difference between any of them. •7min 47Andrew Buelt, DO and Joe Weatherly, DO
Why Cancer Screening Has Never Been Shown to Save LivesFrom December 2016, Ear Pain is but a Memory
Cancer screening is supposed to save lives, but does it actually meet that goal?21min 11Vinay Prasad, MD and Andrew Buelt, DO
Colon Cancer Screening: The BasicsFrom November 2016, Aspirin Loses Its Tenure
The Shark gives a primer on different colon cancer screening tests.11min 11Dave Sharkis, MD
Colon Cancer Screening: The Guidelines and ControversyFrom November 2016, Aspirin Loses Its Tenure
When it comes to colon cancer screening, colonoscopy isn't the only answer. The best test most patients is the one they are most likely to have completed. •10min 8Dave Sharkis, MD
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