Paper Chase #1: The BEYOND Trial for Diabetes
From October 2021, Reducing HarmGlycemic control was similar between all groups, with increased patient satisfaction and less hypoglycemia in the basal-GLP1/SGLT groups
7min 52Steve Biederman, MD and Tom Robertson, MD
Paper Chase #2: Aspirin Dosing in CV Disease
From October 2021, Reducing HarmThere were no significant differences in cardiovascular events or major bleeding between patients assigned to 81 mg and those assigned to 325 mg
7min 30Steve Biederman, MD and Tom Robertson, MD
Paper Chase #3: High-Sensitivity Troponin in Kidney Disease
From October 2021, Reducing HarmHs-trop was more commonly elevated in patients with renal impairment, and these elevations were less frequently attributed to MI.
6min 19Steve Biederman, MD and Tom Robertson, MD
Paper Chase #5: Probiotics to Prevent Antibiotic Associated Diarrhea or C Diff
From October 2021, Reducing HarmProbiotics did not show a statistical difference in the incidence of AAD or CDAD
7min 35Steve Biederman, MD and Tom Robertson, MD
Paper Chase #4: Azithro vs Doxy in Rectal Chlamydia
From October 2021, Reducing HarmA 7-day course of doxycycline was superior to single-dose azithromycin in treatment of rectal chlamydia
5min 6Steve Biederman, MD and Tom Robertson, MD
Paper Chase #4: Blood Pressure Reduction to Prevent CV Disease
From September 2021, Public Health and PandemicsA 5 mmHg reduction in systolic blood pressure reduced the risk of major cardiovascular events by 10% irrespective of previous cardiovascular disease. This was true even at normal baseline blood pressures.
8min 58Tom Robertson, MD and Steve Biederman, MD
Paper Chase #5: Peppermint Oil for IBS Symptoms
From September 2021, Public Health and PandemicsThe data isn’t great, but the potential benefits likely outweigh the risks in a trial of peppermint essential oils for IBS symptoms
9min 5Tom Robertson, MD and Steve Biederman, MD
Paper Chase #1: Beta Blockers & Mortality in Heart Failure Patients on Dialysis
From September 2021, Public Health and PandemicsMetoprolol is associated with a reduction in mortality in patients with HFpEF and new dialysis initiation
8min 12Tom Robertson, MD and Steve Biederman, MD
Paper Chase #2: Weight Loss Maintenance with Exercise, Liraglutide, or Both
From September 2021, Public Health and PandemicsA strategy combining exercise and liraglutide improved healthy weight loss maintenance.
7min 21Tom Robertson, MD and Steve Biederman, MD
Paper Chase #3: Meds for Preschool Kids with ADHD
From September 2021, Public Health and PandemicsBoth were effective, however, stimulants had better efficacy but also overall more adverse events.
7min 25Tom Robertson, MD and Steve Biederman, MD
Paper Chase #1: Trial of Psilocybin versus Escitalopram for Depression
From August 2021, T21, All Grown UpThere was no significant change in depression scores between psilocybin and escitalopram
9min 4Steve Biederman, MD and Tom Robertson, MD
Paper Chase #2: Delayed Antibiotics for Respiratory Tract Infections
From August 2021, T21, All Grown UpImmediate, delayed and no antibiotic prescribing led to similar symptom course, complication rate, and patient satisfaction.
8minSteve Biederman, MD and Tom Robertson, MD
Paper Chase #3: Dapagliflozin in Patients with Chronic Kidney Disease
From August 2021, T21, All Grown UpIn patients with CKD, risk for worsening GFR, ESRD, or death from renal or cardiovascular causes was significantly lower with dapagliflozin
5min 12Steve Biederman, MD and Tom Robertson, MD
Yet More Less is More
From August 2021, T21, All Grown UpPaul and Neda are back at it, continuing their ongoing series on the JAMA Less is More series for reducing unnecessary interventions in primary care.
16min 11Paul Simmons, MD and Neda Frayha, MD
Paper Case #4: Severe Adverse Events Associated with Oral Steroid Bursts in Kids
From August 2021, T21, All Grown UpShort steroid bursts were associated with increased risk of pneumonia, sepsis and GIB within the first 30 days.
6min 58Steve Biederman, MD and Tom Robertson, MD
Paper Chase #5: Preventing Readmission in Comorbid SUD
From August 2021, T21, All Grown UpPatient navigation reduced inpatient readmissions and ED visits in patients with comorbid substance use disorder
8min 58Steve Biederman, MD and Tom Robertson, MD
Paper Chase #1: DOACs vs Warfarin in Valvular A-Fib
From July 2021, Gluten-Free SummerDOACs had improvement in risk of stroke or embolization and less bleeding compared with warfarin in patients with valvular atrial fibrillation, excluding mechanical valves or mitral stenosis.
5min 42Steve Biederman, MD and Tom Robertson, MD
Paper Chase #2: Semaglutide vs Placebo in Weight Loss Maintenance
From July 2021, Gluten-Free SummerAfter a run-in period of subcutaneous semaglutide, patients who continued semaglutide experienced continued weight loss in contrast to placebo where weight was regained.
6min 16Steve Biederman, MD and Tom Robertson, MD
Paper Chase #3: Breastfeeding and Child IQ at Age 5
From July 2021, Gluten-Free SummerThere is an association between breastfeeding and higher IQ scores, but the confounders are complex.
6min 30Steve Biederman, MD and Tom Robertson, MD
Paper Chase #4: Stroke Risk Scores Across All Kidney Function
From July 2021, Gluten-Free SummerModified CHADS2 score performed well and consistently across all kidney function strata.
10min 30Steve Biederman, MD and Tom Robertson, MD
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