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The COMPASS Trial

Casey Parker, MD
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13:36
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This branch of the COMPASS trial examined 3 anticoagulation strategies in patients with “stable atherosclerotic disease”: rivaroxaban 5mg BID, ASA 100mg od + placebo BID, ASA 100 BID + rivaroxaban 2.5 mg BID. Casey’s analysis focused on the ASA groups, not the NOAC alone group. He concludes that the benefits and harms are very closely balanced and while combination therapy may be useful in younger patients, it is associated with increased risk in older patients.

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Chris -

This was a great piece but I think that there might have been a little mistake in the summary around 5:35 when describing the groups. It was said that one group had high-dose rivaroxaban with aspirin, when in fact the high-dose rivaroxaban group did not get aspirin.

Heidi J., MD -

Dang it! You're right. Thanks for picking that up.

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The Tragically Sore Hip Full episode audio for MD edition 196:52 min - 92 MB - M4AHippo Primary Care RAP - February 2018 Written Summary 339 KB - PDF

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