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Paper Chase #4 - Statins for Primary CV Prevention

Tom Robertson, MD and Steve Biederman, MD
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BOTTOM LINE: Statin treatment was associated with reductions in the incidnece of atheroscleortic CVD and all cause mortality in elderly adults age 75-84 with diabetes. In adults age > 74 without diabetes or adults >85 with diabetes, statin treatment was not associated with a reduction in CVD or all cause mortality

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James Copley -

A game changer! Thanks guys
Did they look at targeting a specific LDL level in the diabetic patients, e.g. <2mmol/L, or did patients benefit simply from being on a statin?

Neda F., MD -

Thanks, James. In this article they did not target a specific LDL level in diabetic or non-diabetic patients. The most they looked at the effect of the statin on cholesterol levels is summarized here: " In descriptive analysis, we stratified the exposure of patients to statins according to the cholesterol reduction capacity of these drugs: low (≤30%), moderate (31-40%), high (41-50%), and very high (>50%)." -- Neda

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Into Thin Hair Full episode audio for MD edition 195:41 min - 92 MB - M4APC RAP February 2019 Written Summary 406 KB - PDF

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