Start with a free account for 3 free CME credits. Already a subscriber? Sign in.

Light Chains, SPEPs, and MGUS

Neda Frayha, MD and Victoria Giffi, MD
00:00
23:50
Sign in or subscribe to listen

No me gusta!

The flash player was unable to start. If you have a flash blocker then try unblocking the flash content - it should be visible below.

Kappa? Lambda? SPEPs? MGUS? WTH? Hematologist Dr. Victoria Giffi walks us through a clear, helpful primer on this alphabet soup of immunoglobulins.

To view chapter written summaries, you need to subscribe.

Sign up today for full access to all episodes.

Stephen P. -

If an elevated alpha or beta globulin is noted on spep as part of ruling out myeloma, is that an abnormality requiring a workup and if so what is one looking for? Thanks for an excellent review getting me closer to understanding a challenging topic!

Neda F., MD -

Stephen, we're so glad! Here's Dr. Giffi's response to your question:

"So elevated alpha and beta globulin do not represent a clonal process either. They usually are reflective of inflammation, the cause of which could be many things.

I would think of this workup as similar to that of an elevated ESR or CRP - other nonspecific markers of inflammation. The list includes infections both acute and chronic, autoimmune and malignant."

We hope this helps! Take care -- Neda

To join the conversation, you need to subscribe.

Sign up today for full access to all episodes and to join the conversation.

To download files, you need to subscribe.

Sign up today for full access to all episodes.
Hippo Primary Care Written Summary February 2021 480 KB - PDF

To earn CME for this chapter, you need to subscribe.

Sign up today for full access to all episodes and earn CME.

0.25 Free AMA PRA Category 1 Credits™ certified by Hippo Education or 0.25 Free prescribed credits by the American Academy of Family Physicians certified by AAFP (2021)

  1. Complete Quiz
  2. Complete Evaluation
  3. Print Certificate

3.25 AMA PRA Category 1 Credits™ certified by Hippo Education or 3.25 prescribed credits by the American Academy of Family Physicians certified by AAFP (2021)

  1. Complete Quiz
  2. Complete Evaluation
  3. Print Certificate