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Paper Chase 5: Yet Another Reason to Limit PPI Prescription

Andrew Buelt, DO and Joe Weatherly, DO
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07:08
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No me gusta!

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In patients treated with clopidogrel after successful drug-eluting stents implantation, the concomitant administration of PPI was associated with high platelet reactivity and a greater rate of adverse outcomes during long-term follow-up.

 

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Christopher B. -

Hey guys. Had an idea for a possible future segment: between multiple episodes, you guys have combed through studies and the mounting data on the risks of PPIs. I'd put myself firmly in the perils-of-PPIs camp but, when I've taken my new found knowledge and convictions back to the clinical setting, I'd honestly say my success with getting patients off them and keeping them off them has been consistently disappointing.
I'd love to hear what others are doing who are successfully transitioning patients to H2-blockers. Conversation scripts? Tapering strategies? Other tips?

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The Allergy That Isn't and the B-12 That Is Full episode audio for MD edition 183:18 min - 86 MB - M4AHippo Primary Care RAP February 2016 Summary 735 KB - PDF