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A disorder with fever and rash, no big deal. Internal organ inflammation, big deal. 10% mortality?!? Now you’ve got my attention.
When is a rash not just a rash? When it’s DRESS syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms) -a potentially fatal drug reaction to meds we prescribe every day. Minocycline, lamotrigine, allopurinol and phenytoin are but a few of the offenders that can lead to this potentially fatal disorder.
Cacoub, Patrice, et al. "The DRESS syndrome: a literature review." The American journal of medicine 124.7 (2011): 588-597.
Simonart, S. Tas T. "Management of drug rash with eosinophilia and systemic symptoms (DRESS syndrome): an update." Dermatology 206 (2003): 353-356.