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Paper Chase #1 - Naproxen vs Colchicine for Gout Flares

Steve Biederman, MD and Tom Robertson, MD
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 Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care.

 

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Ian L., Dr -

You do not need such high doses of colchicine .
Colchicine 1G sat and 0.5 G one hour later is all you attempt or often need according to Australian Thereupeutic Guidelines Rheumatology 2019 .
The dose of naprosyn was not mentioned and I believe in the middle aged population hypertension occurs certainly exacerbation CCF .
Colchicine is terrible in overdose there is no antidote so has to be prescibed with great care (Sean Nordt EM rap 2018
Diet restrict purine foods weight loss and booze reduction also works and can help as people get older .
Prednisolone is also quick and efficacious even if one joint is involved a cortisone injection .
Can beDone by Interventional Radiologists with UltraSound nowadays after an diagnostic aspiration .

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Hippo Primary Care RAP Written Summary June 2020 967 KB - PDF

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