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Chapter 1

What’s That Lab? COVID-19 Labs Special Edition!

Paul Simmons, MD and Jay-Sheree Allen, MD

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In this Hippo Education bonus, Dr. Paul Simmons and Dr. Jay-Sheree Allen sit down to discuss what lab studies are recommended on admission of a COVID patient to the hospital, which labs are followed daily, and how they’re best used.

Posted 12/21/2020


  • Click here for a summary table of the discussed labs

  • Wang D., et al. Clinical characteristics of 138 hospitalized patients with 2019 novel Coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020 Mar 17; 323(11):1061-1069. PMID: 32031570

  • Huang C., et al. Clinical features of patients infected with 2019 novel Coronavirus in Wuhan, China. Lancet. 2020 Feb 15; 395(10223):497-506. PMID: 31986264

  • Chen N., et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel Coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020 Feb 15;395(10223):507-513. PMID: 32007143

  • Zhang J-J., et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy. 2020 Jul; 75(7):1730-1741. PMID: 32077115

  • QCOVID risk score: Clift AK, et al. Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study. BMJ. 2020 Oct 20;371:m3731. PMID: 33082154

  • 4C mortality score: Knight SR, et al. Risk stratification of patients admitted to hospital with COVID-19 using the ISARIC WHO Clinical Characterization Protocol: development and validation of the 4C mortality score. BMJ. 2020 Sep 9;370:m3339. PMID: 32907855

  • COR+12 score: Laguna-Goya R, et al. IL-6-based mortality risk model for hospitalized patients with COVID-19. J Allergy Clin Immunol. 2020 Oct;146(4):799-807. PMID: 32710975

  • Seven-factor nomogram: Gong J, et al. A tool for early prediction of severe Coronavirus disease 2019 (COVID-19): a multicenter study using the risk nomogram in Wuhan and Guangdong, China. Clin Infect Dis. 2020 Jul 28;71(15):833-840. PMID: 32296824

  • CALL risk score: Ji D, et al. Prediction for progression risk in patients with COVID-19 pneumonia: the CALL score. Clin Infect Dis. 2020 Sep 12;71(6):1393-1399. PMID: 32271369

  • COVID-GRAM calculator: Liang W., et al. Development and validation of a clinical risk score to predict the occurrence of critical illness in hospitalized patients with COVID-19. JAMA Intern Med. 2020 Aug 1;180(8):1081-1089. PMID: 32396163

  • Elevated D-dimers and lack of anticoagulation predict PE in severe COVID-19 patients. Basile Mouhat, et al. European Respiratory Journal 2020; DOI: 10.1183/13993003.01811-2020. PMID: 32907890

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